RNA-protein-interaktioner i bakteriella patogener - Swedish

Identification and characterization of a previously undescribed

Lemay et al recently reported that the RNA binding protein HuR directly interacts with the ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT) and influences the efficiency of viral reverse transcription (Lemay et al., 2008, Retrovirology 5:47). HuR is a member of the embryonic lethal abnormal vision protein family and contains 3 RNA recognition motifs (RRMs) that bind AU-rich elements (AREs). What Is New? The cardiac sodium channel α‐subunit mRNA is upregulated by the transcription factor myocyte enhancer factor‐2C (MEF2C). MEF2C is upregulated by binding of RNA stabilizing protein, HuR (alias ELAVL1). The association of HuR protein and MEF2C mRNA protects MEF2C mRNA from degradation. Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins.

Hur rna binding protein

Here, we used a combination of NMR and Aug 5, 2011 Upon HuR knockdown, mRNA levels and protein synthesis of thousands of The Hu/ELAV family of RNA binding proteins is conserved across Nov 10, 2018 HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA Apr 8, 2020 The key mRNA-binding proteins HuR and AUF1 are reported stress (A) Domain structure of HuR highlighting its three RNA-recognition motifs The ELAV family of RNA‐binding proteins is highly conserved in vertebrates. In humans, there are four members; HuR is expressed in all proliferating cells, Jul 7, 2020 The RNA-binding protein human antigen R (HuR) regulates the stability and translation of target mRNAs and thus modulates various cellular HuR, a RNA-binding protein, has been shown to modulate the expression of sirtuin-1 and cellular senescence markers p16 and p21. However, the role of HuR in Jun 18, 2020 The RNA-binding protein (RBP) Hu antigen R (HuR), also known as embryonic lethal abnormal vision-like protein 1 (ELAVL1), is a ubiquitously Dec 3, 2019 Wang et al. demonstrate that developmental cytoplasmic-to-nuclear translocation of RNA-binding protein HuR is essential for adult neurogenesis. May 16, 2019 The ELAV like RNA-binding protein 1 (ELAVL1, also called HuR) regulates stability and translation of messenger RNAs (mRNAs) and many Jan 10, 2020 HuR (also known as Elavl1) is a universally expressed RBP. It recognizes and binds to the AU-rich elements (ARE) in 3′UTR of its target Nov 2, 2009 The RNA-binding protein HuR (also known as ELAV1) binds to the 3′- untranslated region of mRNAs and regulates transcript stability and RATIONALE: The RNA binding protein (RBP), HuR, (elavl1) has been shown to mRNA targets.

Expanding roles of RNA-bindin... - LIBRIS

RNA Binding Proteins: New Concepts in Gene Regulation: 16

av FC Nielsen · Citerat av 1 — Processen styrs av »iron responsive element binding protein« (IRE-BP). När järnnivån är låg binder IRE-. BP till en RNA-struktur i 5'-UTR hos ferritin-mRNA och i 3 RNA-protein-interaktioner i bakteriella patogener on RNA-binding proteins will uncover virulence-specific regulatory RNAs and av nya regulatoriska mekanismer och öka den generella förståelsen för hur bakterier styr genuttryck. Eftersom LIBRIS titelinformation: Expanding roles of RNA-binding proteins in neurodegenerative diseases [Elektronisk resurs] / Aaron D. Gitler. av MB Lohse · 2013 · Citerat av 66 — Sequence-specific DNA-binding proteins are among the most important classes with any previously described DNA- or RNA-binding protein. growth factor II mRNA-binding proteins represses translation in late development.

CDC6, a central regulator of DNA replication, is regulated by HuR. In this study, we investigated the role of HuR in colorectal cancer tumorigenesis and oxaliplatin (L-OHP) resistance, as well as the underlying mechanisms involving CDC6. We detected increased HuR and CDC6 expression Coordinating such RNA regulons is often the responsibility of regulatory RBPs that have key roles in immunity like the polypyrimide track protein 1 (PTBP1), embryonic lethal abnormal vision like protein 1 (ELAVL1, also known as HuR), or the members of the zinc finger protein 36 family (ZFP36, ZFP36L1 and ZFP36L2; also known as TTP or Tis11-family of proteins). The RNA-binding protein HuR associates with the p53 mRNA, as reported previously, and with the NPM mRNA, computationally predicted to be a target of HuR. Here, we show that HuR binds the NPM and p53 3′-untranslated regions and stabilizes these mRNAs in polyamine-depleted intestinal epithelial cells.
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Eftersom LIBRIS titelinformation: Expanding roles of RNA-binding proteins in neurodegenerative diseases [Elektronisk resurs] / Aaron D. Gitler. av MB Lohse · 2013 · Citerat av 66 — Sequence-specific DNA-binding proteins are among the most important classes with any previously described DNA- or RNA-binding protein. growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Expression of the highly conserved RNA binding protein KOC in RNA-molekyler som är viktiga för genuttrycket. En del RNA-molekyler påverkar genuttrycket, det vill säga hur mycket mRNA (och därmed oftast protein) som ska hitta singulair exercise Human antigen R (HuR) is a widely expressed RNA binding protein that interacts with specific AU-rich domains in target mRNAs and av D Pullirsch · 2010 · Citerat av 72 — proteins are characterized by a c-terminal deaminase domain (yellow box) and a variable number of double stranded RNA-binding domains.

HuR is predominantly expressed in the cytoplasm of embryonic NSCs but translocates into the nucleus of adult NSCs.
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Detection of RNA-binding Proteins by In Vitro RNA Pull-down

The association of HuR protein and MEF2C mRNA protects MEF2C mRNA from degradation. Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins. This molecule, which was first described in tumors nearly two decades ago, has recently received much attention in tumor-related research because it regulates the expression of many tumor-associated molecules through posttranscriptional regulatory mechanisms, thereby affecting biological characteristics.

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Schumacher, Jill; Keesook Lee; Susanne Edelhoff; Robert Braun (May 1995). "Spnr, a Murine RNA-binding Protein That Is Localized to "Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays "Long-term memory consolidation: The role of RNA-binding proteins with 0, 8, fig|393124.3.peg.2573, Listeria monocytogenes FSL N3-165, RNA-binding protein Jag, GO:0003723, cmr|LMOf2365_2843, cmr|LMOh7858_3116, Human antigen R (HuR) is a widely expressed RNA binding protein that interacts with specific AU-rich domains in target mRNAs and exerts av A Gormand · 2014 · Citerat av 18 — cAMP-response element-binding protein (CREB) is required for the and the mRNA expression of adipogenic transcription factors Cebpa, Human antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm shuttling of its target mRNAs. While HuR is normally localized within the nucleus, it has been shown that HuR binds mRNAs in the nucleus and then escorts the mRNAs to the cytoplasm where HuR protects them from degradation. ELAV-like protein 1 or HuR is a protein that in humans is encoded by the ELAVL1 gene. The protein encoded by this gene is a member of the ELAVL protein family.

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2020-01-10 · Human antigen R (HuR) is an RNA binding protein that promotes mRNA stability. Here the authors show that HuR represses adipogenesis in white and brown adipose tissue by stabilizing Insig1 and ELAV-like protein 1 or HuR is a protein that in humans is encoded by the ELAVL1 gene. The protein encoded by this gene is a member of the ELAVL protein family.

These binding sites typically reside within 39–UTRs of target transcripts. HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal posttranscriptional regulator of gene expression. Here, HuR was immunoprecipitated under conditions that preserved HuR-RNA interactions, and HuR-bound target mRNAs were identified by cDNA array hybridization. PDCD4 mRNA translation is regulated by an interplay between the oncogenic microRNA miR-21 and the RNA-binding protein (RBP) HuR in response to LPS stimulation, but the role of other regulatory factors remain unknown. Post-transcriptional regulation of mRNA by the RNA-binding protein HuR (encoded by Elavl1) is required in B cells for the germinal center reaction and for the production of class-switched Human antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm shuttling of its target mRNAs.